Ontology highlight
ABSTRACT:
SUBMITTER: Owyong M
PROVIDER: S-EPMC6856766 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Life science alliance 20191114 6
Metastasis, the main cause of cancer-related death, has traditionally been viewed as a late-occurring process during cancer progression. Using the MMTV-PyMT luminal B breast cancer model, we demonstrate that the lung metastatic niche is established early during tumorigenesis. We found that matrix metalloproteinase 9 (MMP9) is an important component of the metastatic niche early in tumorigenesis and promotes circulating tumor cells to colonize the lungs. Blocking active MMP9, using a monoclonal a ...[more]