The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies.

ABSTRACT: BACKGROUND:The relationship between serum vitamin D and atrial fibrillation (AF) or postoperative atrial fibrillation (POAF) in patients undergoing coronary artery bypass graft (CABG) is still debated. It is also unclear whether there is a dose-response relationship between circulating vitamin D and the risk of AF or POAF. METHODS:The Cochrane Library, PubMed, and Embase databases were searched for relevant studies. We used a "one-stage approach" with a restricted cubic spline model to summarize the dose-specific relationships between serum vitamin D and AF. Relative risk (RR) was used to measure the effects in this meta-analysis. RESULTS:In total, 13 studies were included with a total of 6519 cases of AF among 74,885 participants. Vitamin D deficiency (< 20 ng/ml) was associated with incr

SUBMITTER: Liu X 

PROVIDER: S-EPMC6857145 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature