Dataset Information

Oscillation-specific nodal alterations in early to middle stages Parkinson's disease.

ABSTRACT: Background:Different oscillations of brain networks could carry different dimensions of brain integration. We aimed to investigate oscillation-specific nodal alterations in patients with Parkinson's disease (PD) across early stage to middle stage by using graph theory-based analysis. Methods:Eighty-eight PD patients including 39 PD patients in the early stage (EPD) and 49 patients in the middle stage (MPD) and 36 controls were recruited in the present study. Graph theory-based network analyses from three oscillation frequencies (slow-5: 0.01-0.027?Hz; slow-4: 0.027-0.073?Hz; slow-3: 0.073-0.198?Hz) were analyzed. Nodal metrics (e.g. nodal degree centrality, betweenness centrality and nodal efficiency) were calculated. Results:Our results showed that (1) a divergent effect of oscillation frequencies on nodal metrics, especially on nodal degree centrality and nodal efficiency, that the anteroventral neocortex and subcortex had high nodal metrics within low oscillation frequencies while the posterolateral neocortex had high values within the relative high oscillation frequency was observed, which visually showed that network was perturbed in PD; (2) PD patients in early stage relatively preserved nodal properties while MPD patients showed widespread abnormalities, which was consistently detected within all three oscillation frequencies; (3) the involvement of basal ganglia could be specifically observed within slow-5 oscillation frequency in MPD patients; (4) logistic regression and receiver operating characteristic curve analyses demonstrated that some of those oscillation-specific nodal alterations had the ability to well discriminate PD patients from controls or MPD from EPD patients at the individual level; (5) occipital disruption within high frequency (slow-3) made a significant influence on motor impairment which was dominated by akinesia and rigidity. Conclusions:Coupling various oscillations could provide potentially useful information for large-scale network and progressive oscillation-specific nodal alterations were observed in PD patients across early to middle stages.

SUBMITTER: Guan X

PROVIDER: S-EPMC6857322 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Oscillation-specific nodal alterations in early to middle stages Parkinson's disease.

Guan Xiaojun X Guo Tao T Zeng Qiaoling Q Wang Jiaqiu J Zhou Cheng C Liu Chunlei C Wei Hongjiang H Zhang Yuyao Y Xuan Min M Gu Quanquan Q Xu Xiaojun X Huang Peiyu P Pu Jiali J Zhang Baorong B Zhang Min-Ming MM

Translational neurodegeneration 20191115

<h4>Background</h4>Different oscillations of brain networks could carry different dimensions of brain integration. We aimed to investigate oscillation-specific nodal alterations in patients with Parkinson's disease (PD) across early stage to middle stage by using graph theory-based analysis.<h4>Methods</h4>Eighty-eight PD patients including 39 PD patients in the early stage (EPD) and 49 patients in the middle stage (MPD) and 36 controls were recruited in the present study. Graph theory-based net ...[more]

PMID: 31807287

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Dataset Information

Oscillation-specific nodal alterations in early to middle stages Parkinson's disease.

Publications

Oscillation-specific nodal alterations in early to middle stages Parkinson's disease.

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