Ontology highlight
ABSTRACT:
SUBMITTER: Garcia EJ
PROVIDER: S-EPMC6857569 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Garcia Enrique J EJ de Jonge Janeska J JJ Liao Pin-Chao PC Stivison Elizabeth E Sing Cierra N CN Higuchi-Sanabria Ryo R Boldogh Istvan R IR Pon Liza A LA
Molecular biology of the cell 20191010 24
Loss of mitochondrial DNA (mtDNA) results in loss of mitochondrial respiratory activity, checkpoint-regulated inhibition of cell cycle progression, defects in growth, and nuclear genome instability. However, after several generations, yeast cells can adapt to the loss of mtDNA. During this adaptation, rho<sup>0</sup> cells, which have no mtDNA, exhibit increased growth rates and nuclear genome stabilization. Here, we report that an immediate response to loss of mtDNA is a decrease in replicative ...[more]