N-cadherin stabilises neural identity by dampening anti-neural signals.
Ontology highlight
ABSTRACT:
SUBMITTER: Punovuori K
PROVIDER: S-EPMC6857587 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
N-cadherin stabilises neural identity by dampening anti-neural signals.
Punovuori Karolina K Migueles Rosa P RP Malaguti Mattias M Blin Guillaume G Macleod Kenneth G KG Carragher Neil O NO Pieters Tim T van Roy Frans F Stemmler Marc P MP Lowell Sally S
Development (Cambridge, England) 20191108 21
A switch from E- to N-cadherin regulates the transition from pluripotency to neural identity, but the mechanism by which cadherins regulate differentiation was previously unknown. Here, we show that the acquisition of N-cadherin stabilises neural identity by dampening anti-neural signals. We use quantitative image analysis to show that N-cadherin promotes neural differentiation independently of its effects on cell cohesiveness. We reveal that cadherin switching diminishes the level of nuclear β- ...[more]
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