Ontology highlight
ABSTRACT:
SUBMITTER: Sutkeviciute I
PROVIDER: S-EPMC6857722 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Sutkeviciute Ieva I Clark Lisa J LJ White Alex D AD Gardella Thomas J TJ Vilardaga Jean-Pierre JP
Trends in endocrinology and metabolism: TEM 20191101 11
The parathyroid hormone (PTH) type 1 receptor (PTHR) is the canonical G protein-coupled receptor (GPCR) for PTH and PTH-related protein (PTHrP) and the key regulator of calcium homeostasis and bone turnover. PTHR function is critical for human health to maintain homeostatic control of ionized serum Ca<sup>2+</sup> levels and has several unusual signaling features, such as endosomal cAMP signaling, that are well-studied but not structurally understood. In this review, we discuss how recently solv ...[more]