Evaluation of Proposed Criteria for Remission and Evidence-Based Development of Criteria for Complete Response in Patients With Chronic Refractory Gout.

ABSTRACT:

Objective

The objective of this study is to assess criteria for gout remission and to use the results to inform criteria for a complete response (CR).

Methods

A post hoc analysis of two clinical trials was undertaken to determine the frequency with which subjects with chronic refractory gout who were treated with pegloticase met remission criteria. Mixed modeling was then employed to identify the components that best correlated with time to maximum benefit.

Results

Of the 56 subjects treated with biweekly pegloticase for whom adequate data were collected, 48.2% met the remission criteria. When subjects with persistent lowering of urate levels were examined separately, 27 of 32 (84.4%) met the criteria for remission. In contrast, even when the requirement for lowering

SUBMITTER: Schlesinger N 

PROVIDER: S-EPMC6857961 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature