Ontology highlight
ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC6858063 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Zhang Chengxiang C Zhang Xinfu X Zhao Weiyu W Zeng Chunxi C Li Wenqing W Li Bin B Luo Xiao X Li Junan J Jiang Justin J Deng Binbin B McComb David W DW Dong Yizhou Y
Nano research 20190201 4
Triple-negative breast cancer (TNBC) is one type of the most aggressive breast cancers with poor prognosis. It is of great urgency to develop new therapeutics for treating TNBC. Based on current treatment guideline and genetic information of TNBC, a combinational therapy platform integrating chemotherapy drugs and mRNA encoding tumor suppressor proteins may become an efficacious strategy. In this study, we developed paclitaxel amino lipid (PAL) derived nanoparticles (NPs) to incorporate both che ...[more]