Ontology highlight
ABSTRACT:
SUBMITTER: Arnold ND
PROVIDER: S-EPMC6858314 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Nature communications 20191115 1
Pulmonary arterial hypertension (PAH) is a rare but fatal disease. Current treatments increase life expectancy but have limited impact on the progressive pulmonary vascular remodelling that drives PAH. Osteoprotegerin (OPG) is increased within serum and lesions of patients with idiopathic PAH and is a mitogen and migratory stimulus for pulmonary artery smooth muscle cells (PASMCs). Here, we report that the pro-proliferative and migratory phenotype in PASMCs stimulated with OPG is mediated via th ...[more]