Ontology highlight
ABSTRACT:
SUBMITTER: Micali G
PROVIDER: S-EPMC6858467 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Micali Gabriele G Endres Robert G RG
Scientific reports 20191115 1
Cells are often considered input-output devices that maximize the transmission of information by converting extracellular stimuli (input) via signaling pathways (communication channel) to cell behavior (output). However, in biological systems outputs might feed back into inputs due to cell motility, and the biological channel can change by mutations during evolution. Here, we show that the conventional channel capacity obtained by optimizing the input distribution for a fixed channel may not ref ...[more]