Ontology highlight
ABSTRACT:
SUBMITTER: Cross KL
PROVIDER: S-EPMC6858544 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Cross Karissa L KL Campbell James H JH Balachandran Manasi M Campbell Alisha G AG Cooper Connor J CJ Griffen Ann A Heaton Matthew M Joshi Snehal S Klingeman Dawn D Leys Eugene E Yang Zamin Z Parks Jerry M JM Podar Mircea M
Nature biotechnology 20190930 11
Most microorganisms from all taxonomic levels are uncultured. Single-cell genomes and metagenomes continue to increase the known diversity of Bacteria and Archaea; however, while 'omics can be used to infer physiological or ecological roles for species in a community, most of these hypothetical roles remain unvalidated. Here, we report an approach to capture specific microorganisms from complex communities into pure cultures using genome-informed antibody engineering. We apply our reverse genomi ...[more]