Ontology highlight
ABSTRACT:
SUBMITTER: Dube U
PROVIDER: S-EPMC6858549 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Dube Umber U Del-Aguila Jorge L JL Li Zeran Z Budde John P JP Jiang Shan S Hsu Simon S Ibanez Laura L Fernandez Maria Victoria MV Farias Fabiana F Norton Joanne J Gentsch Jen J Wang Fengxian F Salloway Stephen S Masters Colin L CL Lee Jae-Hong JH Graff-Radford Neill R NR Chhatwal Jasmeer P JP Bateman Randall J RJ Morris John C JC Karch Celeste M CM Harari Oscar O Cruchaga Carlos C
Nature neuroscience 20191007 11
Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and without Alzheimer disease (AD; n<sub>control</sub> = 13; n<sub>AD</sub> = 83) from the Knight Alzheimer Disease Research Center (Knight ADRC). Using this and an independent (Mount Sinai Brain Bank (MSBB)) AD RNA-seq dataset, cortical circular RNA (circRNA) expression was quantified in the context of AD. Significant associations were identified between circRNA expression and AD diagnosis, clinical dementia seve ...[more]