Ontology highlight
ABSTRACT:
SUBMITTER: Wang G
PROVIDER: S-EPMC6858551 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Wang Guangchuan G Chow Ryan D RD Bai Zhigang Z Zhu Lvyun L Errami Youssef Y Dai Xiaoyun X Dong Matthew B MB Ye Lupeng L Zhang Xiaoya X Renauer Paul A PA Park Jonathan J JJ Shen Li L Ye Hanghui H Fuchs Charles S CS Chen Sidi S
Nature immunology 20191014 11
Immunotherapy has transformed cancer treatment. However, current immunotherapy modalities face various limitations. In the present study, we developed multiplexed activation of endogenous genes as an immunotherapy (MAEGI), a new form of immunotherapy that elicits antitumor immunity through multiplexed activation of endogenous genes in tumors. We leveraged CRISPR activation (CRISPRa) to directly augment the in situ expression of endogenous genes, and thereby the presentation of tumor antigens, le ...[more]