Structural basis of temperature sensation by the TRP channel TRPV3.

ABSTRACT: We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo ?-to-? transitions. During the weakly temperature-dependent second step, channel opening, tight association of the S1-S4 and pore domains is stabilized by changes in the carboxy-terminal and linker domains.

SUBMITTER: Singh AK 

PROVIDER: S-EPMC6858569 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature