Ontology highlight
ABSTRACT:
SUBMITTER: Serhan N
PROVIDER: S-EPMC6858877 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Serhan Nadine N Basso Lilian L Sibilano Riccardo R Petitfils Camille C Meixiong James J Bonnart Chrystelle C Reber Laurent L LL Marichal Thomas T Starkl Philipp P Cenac Nicolas N Dong Xinzhong X Tsai Mindy M Galli Stephen J SJ Gaudenzio Nicolas N
Nature immunology 20191007 11
Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching and type 2 immunity-associated hypersensitivity to widely distributed allergens, including those derived from house dust mites (HDMs). Here we found that HDMs with cysteine protease activity directly activated peptidergic nociceptors, which are neuropeptide-producing nociceptive sensory neurons that express the ion channel TRPV1 and Tac1, the gene encoding the precursor for the neuropeptide substanc ...[more]