Dataset Information

Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study.

ABSTRACT:

Background

Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.

Methods

We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children's Study. The subjects submitted self-administered questionnaires, and blood samples were collected from them twice, specifically, during the first trimester and again during the second/third trimester. Concentrations of the metals Cd, Pb, Hg, Se, and Mn, as well as serum total and allergen-specific IgEs for egg white, house dust-mites (HDM), Japanese cedar pollen (JCP), animal dander, and moth, were measured. Allergen-specific IgE(s) were divided based on concentrations <0.35 or ?0.35 UA/mL, and the metal levels were divided into quartiles.

Results

Multivariable logistic regression analysis showed that there was a significant negative correlation between HDM- and animal dander-specific IgEs and Hg and Mn concentrations. Conversely, there was a significant positive relationship between JCP-specific IgE and Hg and Se concentrations.

Conclusions

Metal exposures may be related to both increases and decreases in allergen-specific IgEs in pregnant women.

SUBMITTER: Tsuji M

PROVIDER: S-EPMC6859078 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Publications

Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study.

Tsuji Mayumi M Koriyama Chihaya C Ishihara Yasuhiro Y Yamamoto Megumi M Yamamoto-Hanada Kiwako K Kanatani Kumiko K Bamai Yu Ait YA Onishi Kazunari K Senju Ayako A Araki Shunsuke S Shibata Eiji E Morokuma Seiichi S Sanefuji Masafumi M Kitazawa Hiroshi H Saito Mayako M Umezawa Masakazu M Onoda Atsuto A Kusuhara Koichi K Tanaka Rie R Kawamoto Toshihiro T

Journal of epidemiology 20190112 12

<h4>Background</h4>Metal exposures could possibly affect allergic responses in pregnant women, although no studies have yet shown a clear relationship between the two, and such exposures might also affect the development of allergic diseases in children.<h4>Methods</h4>We investigated the relationship between metal concentrations in whole blood and immunoglobulin E (IgE; total and specific) in 14,408 pregnant women who participated in the Japan Environment and Children's Study. The subjects subm ...[more]

PMID: 30643099

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Project description:OBJECTIVES:Non-response to questionnaires in a longitudinal study reduces the effective sample size and introduces bias. We identified the characteristics of non-respondent pregnant women, and compared them with respondents in the Japan Environment and Children's Study (JECS) during the gestational period. DESIGN:This was a questionnaire-based, longitudinal cohort study. SETTING:Questionnaires were provided by research coordinators to mothers at prenatal examinations (at obstetrics clinics) or by mail. Mothers were measured twice: during the first trimester and during the second/third trimester. PARTICIPANTS:Data were collected from the 10?129 participating mothers of the 10?288 children surveyed in the 2011 baseline JECS. We excluded responses from mothers who had a miscarriage or stillbirth; therefore, we analysed data from 9649 participants. PRIMARY AND SECONDARY OUTCOME MEASURES:Data concerning demographics, medical history, health characteristics, health-related behaviour and environmental exposure were collected via self-administered questionnaires. The response status of participants' partners and contact with their obstetrician were also examined. Multivariate logistic regression analysis was used to examine factors related to non-response. RESULTS:Response was associated with living with one's mother-in-law (ORs: 0.47, 95% CIs: 0.24 to 0.85), positive participation of participants' partner (OR: 0.25, 95%?CI: 0.17 to 0.35) and multiple visits to the obstetrician (OR: 0.02, 95%?CI: 0.02 to 0.03). Participants who had a medical history of allergic rhinitis, had body pain or drank alcohol had higher odds of responding (ORs: 0.68, 0.96 and 0.36, 95% CIs: 0.48 to 0.95 and 0.95 to 0.98 and 0.16 to 0.72, respectively); those exposed to secondary smoke had lower odds of responding (OR: 1.59, 95%?CI: 1.12 to 2.23). CONCLUSIONS:The non-response rate decreased when participants reported health-related behaviour or characteristics. Obtaining the understanding of people around each participant might help increase response rates.

Dataset Information

Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study.

Background

Methods

Results

Conclusions

Publications

Associations Between Metal Levels in Whole Blood and IgE Concentrations in Pregnant Women Based on Data From the Japan Environment and Children's Study.

Similar Datasets

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