Ontology highlight
ABSTRACT:
SUBMITTER: Hoogerland JA
PROVIDER: S-EPMC6859192 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Hoogerland Joanne A JA Lei Yu Y Wolters Justina C JC de Boer Jan Freark JF Bos Trijnie T Bleeker Aycha A Mulder Niels L NL van Dijk Theo H TH Kuivenhoven Jan A JA Rajas Fabienne F Mithieux Gilles G Haeusler Rebecca A RA Verkade Henkjan J HJ Bloks Vincent W VW Kuipers Folkert F Oosterveer Maaike H MH
Hepatology (Baltimore, Md.) 20190624 6
It is well established that, besides facilitating lipid absorption, bile acids act as signaling molecules that modulate glucose and lipid metabolism. Bile acid metabolism, in turn, is controlled by several nutrient-sensitive transcription factors. Altered intrahepatic glucose signaling in type 2 diabetes associates with perturbed bile acid synthesis. We aimed to characterize the regulatory role of the primary intracellular metabolite of glucose, glucose-6-phosphate (G6P), on bile acid metabolism ...[more]