Tuberculosis diagnosis and treatment under uncertainty.
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ABSTRACT:
SUBMITTER: Cassidy R
PROVIDER: S-EPMC6859331 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Tuberculosis diagnosis and treatment under uncertainty.
Cassidy Rachel R Manski Charles F CF
Proceedings of the National Academy of Sciences of the United States of America 20191029 46
In 2017, 1.6 million people worldwide died from tuberculosis (TB). A new TB diagnostic test-Xpert MTB/RIF from Cepheid-was endorsed by the World Health Organization in 2010. Trials demonstrated that Xpert is faster and has greater sensitivity and specificity than smear microscopy-the most common sputum-based diagnostic test. However, subsequent trials found no impact of introducing Xpert on morbidity and mortality. We present a decision-theoretic model of how a clinician might decide whether to ...[more]
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