Ontology highlight
ABSTRACT:
SUBMITTER: Metrick MA
PROVIDER: S-EPMC6859373 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Metrick Michael A MA do Carmo Ferreira Natalia N Saijo Eri E Hughson Andrew G AG Kraus Allison A Orrú Christina C Miller Michael W MW Zanusso Gianluigi G Ghetti Bernardino B Vendruscolo Michele M Caughey Byron B
Proceedings of the National Academy of Sciences of the United States of America 20191022 46
Recent work with prion diseases and synucleinopathies indicates that accurate diagnostic methods for protein-folding diseases can be based on the ultrasensitive, amplified measurement of pathological aggregates in biospecimens. A better understanding of the physicochemical factors that control the seeded polymerization of such aggregates, and their amplification in vitro, should allow improvements in existing assay platforms, as well as the development of new assays for other proteopathic aggreg ...[more]