Ontology highlight
ABSTRACT:
SUBMITTER: Bonnefont J
PROVIDER: S-EPMC6859502 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Bonnefont Jerome J Tiberi Luca L van den Ameele Jelle J Potier Delphine D Gaber Zachary B ZB Lin Xionghui X Bilheu Angéline A Herpoel Adèle A Velez Bravo Fausto D FD Guillemot François F Aerts Stein S Vanderhaeghen Pierre P
Neuron 20190725 6
During neurogenesis, progenitors switch from self-renewal to differentiation through the interplay of intrinsic and extrinsic cues, but how these are integrated remains poorly understood. Here, we combine whole-genome transcriptional and epigenetic analyses with in vivo functional studies to demonstrate that Bcl6, a transcriptional repressor previously reported to promote cortical neurogenesis, acts as a driver of the neurogenic transition through direct silencing of a selective repertoire of ge ...[more]