Ontology highlight
ABSTRACT:
SUBMITTER: Wang B
PROVIDER: S-EPMC6859904 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Molecular cell 20190409 4
Disturbances in autophagy and stress granule dynamics have been implicated as potential mechanisms underlying inclusion body myopathy (IBM) and related disorders. Yet the roles of core autophagy proteins in IBM and stress granule dynamics remain poorly characterized. Here, we demonstrate that disrupted expression of the core autophagy proteins ULK1 and ULK2 in mice causes a vacuolar myopathy with ubiquitin and TDP-43-positive inclusions; this myopathy is similar to that caused by VCP/p97 mutatio ...[more]