Dataset Information

Helicobacter pylori Infection in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background/aims

Insufficient systematic reviews were conducted in the previous meta-analyses about the prevalence of Helicobacter pylori infection in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the prevalence of H. pylori infection in patients with CKD.

Methods

A systematic review of studies that evaluated the prevalence of H. pylori infection in patients with CKD compared to a control group was performed. Only studies with adult patients were included, and studies with renal transplant recipients or diabetic nephropathy patients were excluded. Random-effects model meta-analyses with sensitivity analyses and subgroup analyses were conducted to confirm the robustness of the main result. A meta-regression analysis was conducted to explore the influence of potential heterogeneity on the outcomes. The methodological quality of the included publications was evaluated using the Risk of Bias Assessment tool for Nonrandomized Studies. Publication bias was also assessed.

Results

In total, 47 studies were identified and analyzed. The total prevalence of H. pylori infection was 48.2% (1,968/4,084) in patients with CKD and 59.3% (4,097/6,908) in the control group. Pooled analysis showed a significantly lower prevalence of H. pylori infection in patients with CKD (vs control group: odds ratio, 0.64; 95% confidence interval, 0.52 to 0.79). Sensitivity analyses revealed consistent results, and meta-regression analysis showed no significant confounders. No publication bias was detected.

Conclusions

The results of this study suggest a lower prevalence of H. pylori infection in patients with CKD.

SUBMITTER: Shin SP

PROVIDER: S-EPMC6860029 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Publications

<i>Helicobacter pylori</i> Infection in Patients with Chronic Kidney Disease: A Systematic Review and Meta-Analysis.

Shin Suk Pyo SP Bang Chang Seok CS Lee Jae Jun JJ Baik Gwang Ho GH

Gut and liver 20191101 6

<h4>Background/aims</h4>Insufficient systematic reviews were conducted in the previous meta-analyses about the prevalence of <i>Helicobacter pylori</i> infection in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the prevalence of <i>H. pylori</i> infection in patients with CKD.<h4>Methods</h4>A systematic review of studies that evaluated the prevalence of <i>H. pylori</i> infection in patients with CKD compared to a control group was performed. Only studies wit ...[more]

PMID: 30970438

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