Parkinson's disease GWAS-linked Park16 carriers show greater motor progression.

ABSTRACT: BACKGROUND:Data on the long-term motor outcomes of genome-wide association study (GWAS)-linked Parkinson disease (PD) carriers are useful for clinical management. OBJECTIVES:To characterise the association between GWAS-linked PARK16 gene variant and disease progression in PD over a 9-year time frame. METHODS:Over a 9-year period, carriers of PARK16 rs11240572 variant and non-carriers were followed up and evaluated using the modified Hoehn and Yahr (H&Y) staging scale and Unified Parkinson's Disease Rating Scale (UPDRS) part III. A longitudinal, linear mixed model was performed to compare the changes of H&Y staging scale, UPDRS motor score and UPDRS subscores between the two groups. RESULTS:A total of 156 patients (41 PARK16 carriers and 115 non-carriers) were evaluated and followed up for

SUBMITTER: Deng X 

PROVIDER: S-EPMC6860401 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature