Diagnostic performance of basal cortisol level at 0900-1300h in adrenal insufficiency.

ABSTRACT:

Objective

An ACTH stimulation test is the standard diagnostic test for adrenal insufficiency (AI). We aimed to investigate the diagnostic performance between serum morning (0800 h) cortisol and serum basal (0900-1300 h) cortisol levels and determine the proper cut-off point to facilitate AI diagnosis to reduce the number of tests.

Methods

A six-year retrospective study was performed in a tertiary care medical center. We identified 416 patients who had undergone either low (LDT) or high dose (HDT) ACTH stimulation outpatient tests. AI was defined as a peak serum cortisol level of <500 nmol/L at 30 or 60 minutes after LDT or HDT. The associations between AI and serum basal and morning cortisol levels were demonstrated by logistic regression model. Diagnostic performance was ev

SUBMITTER: Manosroi W 

PROVIDER: S-EPMC6860436 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature