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A systematic review of comorbidities and outcomes of adult patients with pleural infection.

ABSTRACT: BACKGROUND:Pleural infection remains an important cause of mortality. This study aimed to investigate worldwide patterns of pre-existing comorbidities and clinical outcomes of patients with pleural infection. METHODS:Studies reporting on adults with pleural infection between 2000 and 2017 were identified from a search of Embase and MEDLINE. Articles reporting exclusively on tuberculous, fungal or post-pneumonectomy infection were excluded. Two reviewers assessed 20?980 records for eligibility. RESULTS:211 studies met the inclusion criteria. 134 articles (227?898 patients, mean age 52.8?years) reported comorbidity and/or outcome data. The majority of studies were retrospective observational cohorts (n=104, 78%) and the most common region of reporting was East Asia (n=33, 24%) followed by North America (n=27, 20%). 85 articles (50?756 patients) reported comorbidity. The median (interquartile range (IQR)) percentage prevalence of any comorbidity was 72% (58-83%), with respiratory illness (20%, 16-32%) and cardiac illness (19%, 15-27%) most commonly reported. 125 papers (192?298 patients) reported outcome data. The median (IQR) length of stay was 19?days (13-27 days) and median in-hospital or 30-day mortality was 4% (IQR 1-11%). In regions with high-income economies (n=100, 74%) patients were older (mean 56.5 versus 42.5?years, p<0.0001), but there were no significant differences in prevalence of pre-existing comorbidity nor in length of hospital stay or mortality. CONCLUSION:Patients with pleural infection have high levels of comorbidity and long hospital stays. Most reported data are from high-income economy settings. Data from lower-income regions is needed to better understand regional trends and enable optimal resource provision going forward.

SUBMITTER: Cargill TN

PROVIDER: S-EPMC6860993 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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A systematic review of comorbidities and outcomes of adult patients with pleural infection.

Cargill Tamsin N TN Hassan Maged M Corcoran John P JP Harriss Elinor E Asciak Rachelle R Mercer Rachel M RM McCracken David J DJ Bedawi Eihab O EO Rahman Najib M NM

The European respiratory journal 20190901 3

<h4>Background</h4>Pleural infection remains an important cause of mortality. This study aimed to investigate worldwide patterns of pre-existing comorbidities and clinical outcomes of patients with pleural infection.<h4>Methods</h4>Studies reporting on adults with pleural infection between 2000 and 2017 were identified from a search of Embase and MEDLINE. Articles reporting exclusively on tuberculous, fungal or post-pneumonectomy infection were excluded. Two reviewers assessed 20 980 records for ...[more]

PMID: 31391221

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A systematic review of comorbidities and outcomes of adult patients with pleural infection.

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A systematic review of comorbidities and outcomes of adult patients with pleural infection.

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