Ontology highlight
ABSTRACT:
SUBMITTER: Cardona A
PROVIDER: S-EPMC6861061 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Cardona Andrea A O'Brien Aaron A Bernier Matthew C MC Somogyi Arpad A Wysocki Vicki H VH Smart Suzanne S He Xin X Ambrosio Giuseppe G Hsueh Willa Ann WA Raman Subha V SV
BMJ open diabetes research & care 20191115 1
<h4>Introduction</h4>Type 2 diabetes mellitus (T2D) confers high atherosclerotic cardiovascular disease (ASCVD) risk. The metabolite trimethylamine N-oxide (TMAO) derived via gut flora has been linked to excess ASCVD.<h4>Research design and methods</h4>We analyzed data, biospecimens, and major adverse cardiovascular events (MACEs) from the prospective multicenter randomized Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial to assess its value in 330 high-risk individuals with T2D ...[more]