Ontology highlight
ABSTRACT:
SUBMITTER: Yoon SJ
PROVIDER: S-EPMC6861186 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Yoon Sung-Jin SJ Jo Dong Hyun DH Park Seung-Ho SH Park Jun-Young JY Lee Yoo-Kyung YK Lee Moo-Seung MS Min Jeong-Ki JK Jung Haiyoung H Kim Tae-Don TD Yoon Suk Ran SR Chung Su Wol SW Kim Jeong Hun JH Choi Inpyo I Park Young-Jun YJ
Frontiers in immunology 20191112
In host defense, it is crucial to maintain the acidity of the macrophage phagosome for effective bacterial clearance. However, the mechanisms governing phagosomal acidification upon exposure to gram-negative bacteria have not been fully elucidated. In this study, we demonstrate that in macrophages exposed to <i>Escherichia coli</i>, the thioredoxin-interacting protein (TXNIP)-associated inflammasome plays a role in pH modulation through the activated caspase-1-mediated inhibition of NADPH oxidas ...[more]