Ontology highlight
ABSTRACT:
SUBMITTER: Xu WN
PROVIDER: S-EPMC6861227 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Xu Wen-Ning WN Zheng Huo-Liang HL Yang Run-Ze RZ Liu Tao T Yu Wei W Zheng Xin-Feng XF Li Bo B Jiang Sheng-Dan SD Jiang Lei-Sheng LS
Experimental & molecular medicine 20191118 11
The main pathological mechanism of intervertebral disc degeneration (IVDD) is the programmed apoptosis of nucleus pulposus (NP) cells. Oxidative stress is a significant cause of IVDD. Whether mitophagy is induced by strong oxidative stress in IVDD remains to be determined. This study aimed to investigate the relationship between oxidative stress and mitophagy and to better understand the mechanism of IVDD in vivo and in vitro. To this end, we obtained primary NP cells from the human NP and subse ...[more]