Ontology highlight
ABSTRACT:
SUBMITTER: Demouveaux B
PROVIDER: S-EPMC6861317 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Demouveaux Bastien B Gouyer Valérie V Robbe-Masselot Catherine C Gottrand Frédéric F Narita Tetsuharu T Desseyn Jean-Luc JL
Scientific reports 20191118 1
Mucus is the first biological barrier encountered by particles and pathogenic bacteria at the surface of secretory epithelia. The viscoelasticity of mucus is governed in part by low energy interactions that are difficult to assess. The CYS domain is a good candidate to support low energy interactions between GFMs and/or mucus constituents. Our aim was to stiffen the mucus from HT29-MTX cell cocultures and the colon of mice through the delivery of a recombinant protein made of hydrophobic CYS dom ...[more]