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Run length distribution of dimerized kinesin-3 molecular motors: comparison with dimeric kinesin-1.

ABSTRACT: Kinesin-3 and kinesin-1 molecular motors are two families of the kinesin superfamily. It has been experimentally revealed that in monomeric state kinesin-3 is inactive in motility and cargo-mediated dimerization results in superprocessive motion, with an average run length being more than 10-fold longer than that of kinesin-1. In contrast to kinesin-1 showing normally single-exponential distribution of run lengths, dimerized kinesin-3 shows puzzlingly Gaussian distribution of run lengths. Here, based on our proposed model, we studied computationally the dynamics of kinesin-3 and compared with that of kinesin-1, explaining quantitatively the available experimental data and revealing the origin of superprocessivity and Gaussian run length distribution of kinesin-3. Moreover, predicted results are provided on ATP-concentration dependence of run length distribution and force dependence of mean run length and dissociation rate of kinesin-3.

SUBMITTER: Guo SK

PROVIDER: S-EPMC6861319 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Run length distribution of dimerized kinesin-3 molecular motors: comparison with dimeric kinesin-1.

Guo Si-Kao SK Shi Xiao-Xuan XX Wang Peng-Ye PY Xie Ping P

Scientific reports 20191118 1

Kinesin-3 and kinesin-1 molecular motors are two families of the kinesin superfamily. It has been experimentally revealed that in monomeric state kinesin-3 is inactive in motility and cargo-mediated dimerization results in superprocessive motion, with an average run length being more than 10-fold longer than that of kinesin-1. In contrast to kinesin-1 showing normally single-exponential distribution of run lengths, dimerized kinesin-3 shows puzzlingly Gaussian distribution of run lengths. Here, ...[more]

PMID: 31740721

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