Bioinformatics analysis of hepatic gene expression profiles in type 2 diabetes mellitus.
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ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC6861877 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
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Bioinformatics analysis of hepatic gene expression profiles in type 2 diabetes mellitus.
Chen Zhe Z Yuan Weiqu W Liu Tao T Huang Danping D Xiang Lei L
Experimental and therapeutic medicine 20191010 6
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia. The liver has a critical role in regulating glucose homeostasis. The present study aimed to analyze hepatic gene expression profiles and to identify the key genes and pathways involved in T2DM. Gene expression profiles of 10 patients with T2DM and 7 subjects with normal glucose tolerance were downloaded from the Gene Expression Omnibus database. Subsequently, differentially expressed genes (DEGs) were identified and functional en ...[more]
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