Ontology highlight
ABSTRACT:
SUBMITTER: Nakanishi H
PROVIDER: S-EPMC6862407 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Neural regeneration research 20200101 1
Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer's disease, Parkinson's disease, stroke and persistent pain. Activated microglia are the main cellular source of interleukin-1β in the brain. Cathepsin B is associated with the production and secretion of interleukin-1β through pyrin domain-containing protein 3 inflammasome-independent processing of procaspase-3 in the phag ...[more]