Ontology highlight
ABSTRACT:
SUBMITTER: Petkov P
PROVIDER: S-EPMC6862524 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Petkov Peicho P Lilkova Elena E Ilieva Nevena N Litov Leandar L
International journal of molecular sciences 20191101 21
Antimicrobial peptides (AMPs) are a diverse group of membrane-active peptides which play a crucial role as mediators of the primary host defense against microbial invasion. Many AMPs are found to be fully or partially disordered in solution and to acquire secondary structure upon interaction with a lipid membrane. Here, we report molecular dynamics simulations studies on the solution behaviour of a specific AMP, bombinin H2. We show that in monomeric form in water solution the peptide is somewha ...[more]