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Contrast Agent Microbubble Jetting during Initial Interaction with 200-kHz Focused Ultrasound.

ABSTRACT: The initial response of microbubbles flowing through a 500-?m polycarbonate capillary to a burst of 200-kHz focused ultrasound, at peak-negative pressure amplitudes from 0.7-1.5 MPa, was investigated with dual-perspective high-speed imaging. Directed jetting through the acoustic focus is demonstrated according to the pressure gradients acting across the cavitating microbubbles. At lower amplitudes, repeated microbubble-jetting is accompanied by sudden, intermittent translation. At higher amplitudes a rebound jet also forms, before disintegration into a cavitation cloud.

SUBMITTER: Cleve S

PROVIDER: S-EPMC6863384 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Contrast Agent Microbubble Jetting during Initial Interaction with 200-kHz Focused Ultrasound.

Cleve Sarah S Inserra Claude C Prentice Paul P

Ultrasound in medicine & biology 20190830 11

The initial response of microbubbles flowing through a 500-μm polycarbonate capillary to a burst of 200-kHz focused ultrasound, at peak-negative pressure amplitudes from 0.7-1.5 MPa, was investigated with dual-perspective high-speed imaging. Directed jetting through the acoustic focus is demonstrated according to the pressure gradients acting across the cavitating microbubbles. At lower amplitudes, repeated microbubble-jetting is accompanied by sudden, intermittent translation. At higher amplitu ...[more]

PMID: 31477370

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