Ontology highlight
ABSTRACT:
SUBMITTER: Baral PK
PROVIDER: S-EPMC6863700 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20191025 12
Prion diseases in mammals are caused by a conformational transition of the cellular prion protein from its native conformation (PrP<sup>C</sup> ) to a pathological isoform called "prion protein scrapie" (PrP<sup>Sc</sup> ). A molecular level of understanding of this conformational transition will be helpful in unveiling the disease etiology. Experimental structural biological techniques (NMR and X-ray crystallography) have been used to unravel the atomic level structural information for the prio ...[more]