Ontology highlight
ABSTRACT:
SUBMITTER: Chalupska D
PROVIDER: S-EPMC6863706 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Chalupska Dominika D Różycki Bartosz B Klima Martin M Boura Evzen E
Protein science : a publication of the Protein Society 20191017 12
Many picornaviruses hijack the Golgi resident Acyl-coenzyme A binding domain containing 3 (ACBD3) protein in order to recruit the phosphatidylinositol 4-kinase B (PI4KB) to viral replication organelles (ROs). PI4KB, once recruited and activated by ACBD3 protein, produces the lipid phosphatidylinositol 4-phosphate (PI4P), which is a key step in the biogenesis of viral ROs. To do so, picornaviruses use their small nonstructural protein 3A that binds the Golgi dynamics domain of the ACBD3 protein. ...[more]