Ontology highlight
ABSTRACT:
SUBMITTER: Nassar OM
PROVIDER: S-EPMC6863735 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Nassar Omneya M OM Wong Ka-Yiu KY Lynch Gillian C GC Smith Thomas J TJ Pettitt B Montgomery BM
Protein science : a publication of the Protein Society 20191101 12
Glutamate dehydrogenase (GDH) is a target for treating insulin-related disorders, such as hyperinsulinism hyperammonemia syndrome. Modeling native ligand binding has shown promise in designing GDH inhibitors and activators. Our computational investigation of the nicotinamide adenine diphosphate hydride (NADH)/adenosine diphosphate (ADP) site presented in this paper provides insight into the opposite allosteric effects induced at a single site of binding inhibitor NADH versus activator ADP to GDH ...[more]