Ontology highlight
ABSTRACT:
SUBMITTER: Grela E
PROVIDER: S-EPMC6864243 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Grela Ewa E Zdybicka-Barabas Agnieszka A Pawlikowska-Pawlega Bozena B Cytrynska Malgorzata M Wlodarczyk Monika M Grudzinski Wojciech W Luchowski Rafal R Gruszecki Wieslaw I WI
Scientific reports 20191119 1
Amphotericin B is an antibiotic used as the "gold standard" in the treatment of life-threatening fungal infections. Several molecular mechanisms have been proposed to explain exceptionally high effectiveness of amphotericin B in combating fungi. In the present work, we apply fluorescence lifetime imaging microscopy to track, step by step, modes of the toxic activity of amphotericin B towards a clinical strain of Candida albicans. The images recorded reveal that the antibiotic binds to cells in t ...[more]