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Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of ?-Chloroglycinates.

ABSTRACT: A catalyst-free heterocyclization reaction of ?-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.

SUBMITTER: Tomassetti M

PROVIDER: S-EPMC6864457 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates.

Tomassetti Mara M Lupidi Gabriele G Piermattei Pamela P Rossi Federico V FV Lillini Samuele S Bianchini Gianluca G Aramini Andrea A Ciufolini Marco A MA Marcantoni Enrico E

Molecules (Basel, Switzerland) 20191025 21

A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds. ...[more]

PMID: 31731437

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