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Can we make Chitosan by Enzymatic Deacetylation of Chitin?


ABSTRACT: Chitin, an insoluble linear polymer of ?-1,4-N-acetyl-d-glucosamine (GlcNAc; A), can be converted to chitosan, a soluble heteropolymer of GlcNAc and d-glucosamine (GlcN; D) residues, by partial deacetylation. In nature, deacetylation of chitin is catalyzed by enzymes called chitin deacetylases (CDA) and it has been proposed that CDAs could be used to produce chitosan. In this work, we show that CDAs can remove up to approximately 10% of N-acetyl groups from two different (? and ?) chitin nanofibers, but cannot produce chitosan.

SUBMITTER: Harmsen RAG 

PROVIDER: S-EPMC6864559 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Can we make Chitosan by Enzymatic Deacetylation of Chitin?

Harmsen Rianne A G RAG   Tuveng Tina R TR   Antonsen Simen G SG   Eijsink Vincent G H VGH   Sørlie Morten M  

Molecules (Basel, Switzerland) 20191026 21


Chitin, an insoluble linear polymer of β-1,4-<i>N</i>-acetyl-d-glucosamine (GlcNAc; A), can be converted to chitosan, a soluble heteropolymer of GlcNAc and d-glucosamine (GlcN; D) residues, by partial deacetylation. In nature, deacetylation of chitin is catalyzed by enzymes called chitin deacetylases (CDA) and it has been proposed that CDAs could be used to produce chitosan. In this work, we show that CDAs can remove up to approximately 10% of <i>N</i>-acetyl groups from two different (α and β)  ...[more]

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