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Axially Ligated Mesohemins as Bio-Mimicking Catalysts for Atom Transfer Radical Polymerization.

ABSTRACT: Copper is the most common metal catalyst used in atom transfer radical polymerization (ATRP), but iron is an excellent alternative due to its natural abundance and low toxicity compared to copper. In this work, two new iron-porphyrin-based catalysts inspired by naturally occurring proteins, such as horseradish peroxidase, hemoglobin, and cytochrome P450, were synthesized and tested for ATRP. Natural protein structures were mimicked by attaching imidazole or thioether groups to the porphyrin, leading to increased rates of polymerization, as well as providing polymers with low dispersity, even in the presence of ppm amounts of catalysts.

SUBMITTER: Fu L

PROVIDER: S-EPMC6864814 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Axially Ligated Mesohemins as Bio-Mimicking Catalysts for Atom Transfer Radical Polymerization.

Fu Liye L Simakova Antonina A Park Sangwoo S Wang Yi Y Fantin Marco M Matyjaszewski Krzysztof K

Molecules (Basel, Switzerland) 20191102 21

Copper is the most common metal catalyst used in atom transfer radical polymerization (ATRP), but iron is an excellent alternative due to its natural abundance and low toxicity compared to copper. In this work, two new iron-porphyrin-based catalysts inspired by naturally occurring proteins, such as horseradish peroxidase, hemoglobin, and cytochrome P450, were synthesized and tested for ATRP. Natural protein structures were mimicked by attaching imidazole or thioether groups to the porphyrin, lea ...[more]

PMID: 31684005

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