Ontology highlight
ABSTRACT:
SUBMITTER: Poli G
PROVIDER: S-EPMC6865014 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Poli Giulio G Dimmito Marilisa Pia MP Mollica Adriano A Zengin Gokhan G Benyhe Sandor S Zador Ferenc F Stefanucci Azzurra A
Molecules (Basel, Switzerland) 20191027 21
Morphine, oxycodone, fentanyl, and other µ-opioid receptors (MOR) agonists have been used for decades in antinociceptive therapies. However, these drugs are associated with numerous side effects, such as euphoria, addiction, respiratory depression, and adverse gastrointestinal reactions, thus, circumventing these drawbacks is of extensive importance. With the aim of identifying novel peptide ligands endowed with MOR inhibitory activity, we developed a virtual screening protocol, including recept ...[more]