Ontology highlight
ABSTRACT:
SUBMITTER: Lenting K
PROVIDER: S-EPMC6865071 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Lenting Krissie K van den Heuvel Corina N A M CNAM van Ewijk Anne A ElMelik Duaa D de Boer Remco R Tindall Elizabeth E Wei Ge G Kusters Benno B Te Dorsthorst Maarten M Ter Laan Mark M Huynen Martijn A MA Leenders William P WP
Acta neuropathologica communications 20191120 1
Many biology-based precision drugs are available that neutralize aberrant molecular pathways in cancer. Molecular heterogeneity and the lack of reliable companion diagnostic biomarkers for many drugs makes targeted treatment of cancer inaccurate for many individuals. Identifying actionable hyperactive biological pathways in individual cancers may improve this situation.To achieve this we applied a novel targeted RNA next generation sequencing (t/RNA-NGS) technique to surgically obtained glioma t ...[more]