Association of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism.

ABSTRACT:

Importance

Testosterone therapy is increasingly prescribed in patients without a diagnosis of hypogonadism. This therapy may be associated with increased risk of venous thromboembolism (VTE) through several mechanisms, including elevated hematocrit levels, which increase blood viscosity.

Objective

To assess whether short-term testosterone therapy exposure is associated with increased short-term risk of VTE in men with and without evidence of hypogonadism.

Design, setting, and participants

This case-crossover study analyzed data on 39 622 men from the IBM MarketScan Commercial Claims and Encounter Database and the Medicare Supplemental Database from January 1, 2011, to December 31, 2017, with 12 months of follow-up. Men with VTE cases who were free of cancer at baselin

SUBMITTER: Walker RF 

PROVIDER: S-EPMC6865248 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature