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Load effects on spatial working memory performance are linked to distributed alpha and beta oscillations.

ABSTRACT: Increasing spatial working memory (SWM) load is generally associated with declines in behavioral performance, but the neural correlates of load-related behavioral effects remain poorly understood. Herein, we examine the alterations in oscillatory activity that accompany such performance changes in 22 healthy adults who performed a two- and four-load SWM task during magnetoencephalography (MEG). All MEG data were transformed into the time-frequency domain and significant oscillatory responses were imaged separately per load using a beamformer. Whole-brain correlation maps were computed using the load-related beamformer difference images and load-related accuracy effects on the SWM task. The results indicated that load-related differences in left inferior frontal alpha activity during encoding and maintenance were negatively correlated with load-related accuracy differences on the SWM task. That is, individuals who had more substantial decreases in prefrontal alpha during high-relative to low-load SWM trials tended to have smaller performance decrements on the high-load condition (i.e., they performed more accurately). The same pattern of neurobehavioral correlations was observed during the maintenance period for right superior temporal alpha activity and right superior parietal beta activity. Importantly, this is the first study to employ a voxel-wise whole-brain approach to significantly link load-related oscillatory differences and load-related SWM performance differences.

SUBMITTER: Proskovec AL

PROVIDER: S-EPMC6865445 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Load effects on spatial working memory performance are linked to distributed alpha and beta oscillations.

Proskovec Amy L AL Wiesman Alex I AI Heinrichs-Graham Elizabeth E Wilson Tony W TW

Human brain mapping 20190511 12

Increasing spatial working memory (SWM) load is generally associated with declines in behavioral performance, but the neural correlates of load-related behavioral effects remain poorly understood. Herein, we examine the alterations in oscillatory activity that accompany such performance changes in 22 healthy adults who performed a two- and four-load SWM task during magnetoencephalography (MEG). All MEG data were transformed into the time-frequency domain and significant oscillatory responses wer ...[more]

PMID: 31077487

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Project description:Alpha band (8-12 Hz) phase dynamics in the visual cortex are thought to reflect fluctuations in cortical excitability that influences perceptual processing. As such, visual stimuli are better detected when their onset is concurrent with specific phases of the alpha cycle. However, it is unclear whether alpha phase differentially influences cognitive performance at specific times relative to stimulus onset (i.e., is the influence of phase maximal before, at, or after stimulus onset?). To address this, participants performed a delayed-recognition, working memory (WM) task for visual motion direction during two separate visits. The first visit utilized functional magnetic resonance (fMRI) imaging to identify neural regions associated with task performance. Replicating previous studies, fMRI data showed engagement of visual cortical area V5, as well as a prefrontal cortical region, the inferior frontal junction (IFJ). During the second visit, transcranial magnetic stimulation (TMS) was applied separately to both the right IFJ and right V5 (with the vertex as a control region) while electroencephalography (EEG) was simultaneously recorded. During each trial, a single pulse of TMS (spTMS) was applied at one of six time points (-200, -100, -50, 0, 80, 160 ms) relative to the encoded stimulus onset. Results demonstrated a relationship between the phase of the posterior alpha signal prior to stimulus encoding and subsequent response times to the memory probe two seconds later. Specifically, spTMS to V5, and not the IFJ or vertex, yielded faster response times, indicating improved WM performance, when delivered during the peak, compared to the trough, of the alpha cycle, but only when spTMS was applied 100 ms prior to stimulus onset. These faster responses to the probe correlated with decreased early event related potential (ERP) amplitudes (i.e., P1) to the probe stimuli. Moreover, participants that were least affected by spTMS exhibited greater functional connectivity between V5 and fronto-parietal regions. These results suggest that posterior alpha phase indexes a critical time period for motion processing in the context of WM encoding goals, which occurs in anticipation of stimulus onset.

Project description:BackgroundFrontal midline theta (FMT) oscillations (4-8 Hz) are strongly related to cognitive and executive control during mental tasks such as memory processing, arithmetic problem solving or sustained attention. While maintenance of temporal order information during a working memory (WM) task was recently linked to FMT phase, a positive correlation between FMT power, WM demand and WM performance was shown. However, the relationship between these measures is not well understood, and it is unknown whether purposeful FMT phase manipulation during a WM task impacts FMT power and WM performance. Here we present evidence that FMT phase manipulation mediated by transcranial alternating current stimulation (tACS) can block WM demand-related FMT power increase (FMTΔpower) and disrupt normal WM performance.MethodsTwenty healthy volunteers were assigned to one of two groups (group A, group B) and performed a 2-back task across a baseline block (block 1) and an intervention block (block 2) while 275-sensor magnetoencephalography (MEG) was recorded. After no stimulation was applied during block 1, participants in group A received tACS oscillating at their individual FMT frequency over the prefrontal cortex (PFC) while group B received sham stimulation during block 2. After assessing and mapping phase locking values (PLV) between the tACS signal and brain oscillatory activity across the whole brain, FMT power and WM performance were assessed and compared between blocks and groups.ResultsDuring block 2 of group A but not B, FMT oscillations showed increased PLV across task-related cortical areas underneath the frontal tACS electrode. While WM task-related FMTΔpower and WM performance were comparable across groups in block 1, tACS resulted in lower FMTΔpower and WM performance compared to sham stimulation in block 2.ConclusiontACS-related manipulation of FMT phase can disrupt WM performance and influence WM task-related FMTΔpower. This finding may have important implications for the treatment of brain disorders such as depression and attention deficit disorder associated with abnormal regulation of FMT activity or disorders characterized by dysfunctional coupling of brain activity, e.g., epilepsy, Alzheimer's or Parkinson's disease (AD/PD).

Dataset Information

Load effects on spatial working memory performance are linked to distributed alpha and beta oscillations.

Publications

Load effects on spatial working memory performance are linked to distributed alpha and beta oscillations.

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