Dataset Information

Altered structural and functional brain network overall organization predict human intertemporal decision-making.

ABSTRACT: Intertemporal decision-making is naturally ubiquitous to us: individuals always make a decision with different consequences occurring at different moments. These choices are invariably involved in life-changing outcomes regarding marriage, education, fertility, long-term well-being, and even public policy. Previous studies have clearly uncovered the neurobiological mechanism of the intertemporal decision in the schemes of regional location or sub-network. However, it still remains unclear how to characterize intertemporal behavior with multimodal whole-brain network metrics to date. Here, we combined diffusion tensor image and resting-state functional connectivity MRI technology, in conjunction with graph-theoretical analysis, to explore the link between topological properties of integrated structural and functional whole-brain networks and intertemporal decision-making. Graph-theoretical analysis illustrated that the participants with steep discounting rates exhibited the decreased global topological organizations including small-world and rich-club regimes in both functional and structural connectivity networks, and reflected the dreadful local topological dynamics in the modularity of functional connectome. Furthermore, in the cross-modalities configuration, the same relationship was predominantly observed for the coupling of structural-functional connectivity as well. Above topological metrics are commonly indicative of the communication pattern of simultaneous global and local parallel information processing, and it thus reshapes our accounts on intertemporal decision-making from functional regional/sub-network scheme to multimodal brain overall organization.

SUBMITTER: Chen Z

PROVIDER: S-EPMC6865623 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Altered structural and functional brain network overall organization predict human intertemporal decision-making.

Chen Zhiyi Z Hu Xingwang X Chen Qi Q Feng Tingyong T Feng Tingyong T

Human brain mapping 20180921 1

Intertemporal decision-making is naturally ubiquitous to us: individuals always make a decision with different consequences occurring at different moments. These choices are invariably involved in life-changing outcomes regarding marriage, education, fertility, long-term well-being, and even public policy. Previous studies have clearly uncovered the neurobiological mechanism of the intertemporal decision in the schemes of regional location or sub-network. However, it still remains unclear how to ...[more]

PMID: 30240495

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Project description:Adolescent drug misuse represents a major risk factor for long-term drug use disorders. However, wide individual differences in responses to first-line behavioral therapies targeting adolescent drug misuse limit critical early intervention. Identifying the neural signatures of those adolescents most likely to respond to an intervention would potentially guide personalized strategies for reducing drug misuse. Prior to a 14-week evidence-based intervention involving combinations of contingency management, motivational enhancement, and cognitive behavioral therapy, thirty adolescent alcohol and/or cannabis users underwent fMRI while performing a reward delay discounting (DD) task tapping an addiction-related cognition. Intervention responses were longitudinally characterized by both urinalysis and self-report measures of the percentage of days used during treatment and in post-treatment follow-up. Group independent component analysis (ICA) of task fMRI data identified neural processing networks related to DD task performance. Separate measures of wholesale recruitment during immediate reward choices and within-network functional connectivity among selective networks significantly predicted intervention-related changes in drug misuse frequency. Specifically, heightened pre-intervention engagement of a temporal lobe "reward motivation" network for impulsive choices on the DD task predicted poorer intervention outcomes, while modes of functional connectivity within the reward motivation network, a prospection network, and a posterior insula network demonstrated robust associations with intervention outcomes. Finally, the pre-intervention functional organization of the prospection network also predicted post-intervention drug use behaviors for up to 6 months of follow-up. Multiple functional variations in the neural processing networks supporting preference for immediate and future rewards signal individual differences in readiness to benefit from an effective behavioral therapy for reducing adolescent drug misuse. The implications for efforts to boost therapy responses are discussed.

Dataset Information

Altered structural and functional brain network overall organization predict human intertemporal decision-making.

Publications

Altered structural and functional brain network overall organization predict human intertemporal decision-making.

Similar Datasets

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