Mutant-allele tumor heterogeneity in malignant glioma effectively predicts neoplastic recurrence.

ABSTRACT: Intra-tumor heterogeneity (ITH) is one of the most important causes of therapy resistance, which eventually leads to the poor outcomes observed in patients with glioma. Mutant-allele tumor heterogeneity (MATH) values are based on whole-exon sequencing and precisely reflect genetic ITH. However, the significance of MATH values in predicting glioma recurrence remains unclear. Information of patients with glioma was obtained from The Cancer Genome Atlas database. The present study calculated the MATH value for each patient, analyzed the distributions of MATH values in different subtypes and investigated the rates of clinical recurrence in patients with different MATH values. Gene enrichment and Cox regression analyses were performed to determine which factors influenced recurrence. A nomogram

SUBMITTER: Wu P 

PROVIDER: S-EPMC6865645 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature