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Brain gray matter correlates of extraversion: A systematic review and meta-analysis of voxel-based morphometry studies.

ABSTRACT: Extraversion is a fundamental personality dimension closely related to an individual's life outcomes and mental health. Although an increasing number of studies have attempted to identify the neurostructural markers of extraversion, the results have been highly inconsistent. The current study aimed to achieve a comprehensive understanding of brain gray matter (GM) correlates of extraversion with a systematic review and meta-analysis approach. Our review showed relatively high interstudy heterogeneity among previous findings. Our meta-analysis of whole-brain voxel-based morphometry studies revealed that extraversion was stably associated with six core brain regions. Additionally, meta-regression analyses identified brain regions where the associations of extraversion with GM volume were modulated by gender and age. The relationships between extraversion and GM structures were discussed based on three extraversion-related functional systems. Furthermore, we explained the gender and age effects. Overall, our study is the first to reveal a comprehensive picture of brain GM correlates of extraversion, and the findings may be useful for the selection of targeted brain areas for extraversion interventions.

SUBMITTER: Lai H

PROVIDER: S-EPMC6865809 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Brain gray matter correlates of extraversion: A systematic review and meta-analysis of voxel-based morphometry studies.

Lai Han H Wang Song S Zhao Yajun Y Zhang Lei L Yang Cheng C Gong Qiyong Q

Human brain mapping 20190606 14

Extraversion is a fundamental personality dimension closely related to an individual's life outcomes and mental health. Although an increasing number of studies have attempted to identify the neurostructural markers of extraversion, the results have been highly inconsistent. The current study aimed to achieve a comprehensive understanding of brain gray matter (GM) correlates of extraversion with a systematic review and meta-analysis approach. Our review showed relatively high interstudy heteroge ...[more]

PMID: 31169966

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Project description:Introduction: Adolescent-onset cannabis use is rising in the era of marijuana legalization. Recent imaging studies have identified neuroanatomical differences between adult cannabis users and controls that are more prominent in early-onset users. Other studies point to sex-dependent effects of cannabis. Methods: A systematic review following PRISMA guidelines and subsequent effect-size seed-based d mapping (SDM) meta-analyses were conducted to investigate relationships between age (across the 12-to-21-year-old developmental window), sex, and gray matter volume (GMV) differences between cannabis using (CU) and typically developing (TD) youth. Results: Our search identified 1,326 citations, 24 of which were included in a qualitative analysis. A total of 6 whole-brain voxel-based morphometry (VBM) studies comparing regional GMV between 357 CU [mean (SD) age = 16.68 (1.28); 71% male] and 404 TD [mean (SD) age = 16.77 (1.36); 63% male] youth were included in the SDM-meta-analysis. Meta-analysis of whole-brain VBM studies identified no regions showing significant GMV difference between CU and TD youth. Meta-regressions showed divergent effects of age and sex on cortical GMV differences in CU vs. TD youth. Age effects were seen in the superior temporal gyrus (STG), with older-aged CU youth showing decreased and younger-aged CU youth showing increased STG GMV compared to age-matched TD youth. Parallel findings in the STG were also observed in relation to duration of CU (years) in supplemental meta-regressions. Regarding sex effects, a higher proportion of females in studies was associated with increased GMV in the middle occipital gyrus in CU vs. TD youth. Conclusions: These findings suggest that GMV differences between CU and TD youth, if present, are subtle, and may vary as a function of age, cumulative cannabis exposure, and sex in young people. Whether age- and sex-related GMV differences are attributable to common predispositional factors, cannabis-induced neuroadaptive changes, or both warrant further investigation.

Dataset Information

Brain gray matter correlates of extraversion: A systematic review and meta-analysis of voxel-based morphometry studies.

Publications

Brain gray matter correlates of extraversion: A systematic review and meta-analysis of voxel-based morphometry studies.

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