Ontology highlight
ABSTRACT:
SUBMITTER: Mathys H
PROVIDER: S-EPMC6865822 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Mathys Hansruedi H Davila-Velderrain Jose J Peng Zhuyu Z Gao Fan F Mohammadi Shahin S Young Jennie Z JZ Menon Madhvi M He Liang L Abdurrob Fatema F Jiang Xueqiao X Martorell Anthony J AJ Ransohoff Richard M RM Hafler Brian P BP Bennett David A DA Kellis Manolis M Tsai Li-Huei LH
Nature 20190501 7761
Alzheimer's disease is a pervasive neurodegenerative disorder, the molecular complexity of which remains poorly understood. Here, we analysed 80,660 single-nucleus transcriptomes from the prefrontal cortex of 48 individuals with varying degrees of Alzheimer's disease pathology. Across six major brain cell types, we identified transcriptionally distinct subpopulations, including those associated with pathology and characterized by regulators of myelination, inflammation, and neuron survival. The ...[more]