Subclinical depressive symptoms during late midlife and structural brain alterations: A longitudinal study of Danish men born in 1953.
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SUBMITTER: Osler M
PROVIDER: S-EPMC6866324 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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Subclinical depressive symptoms during late midlife and structural brain alterations: A longitudinal study of Danish men born in 1953.
Osler Merete M Sørensen Lauge L Rozing Maarten M Calvo Oriol Puig OP Nielsen Mads M Rostrup Egill E
Human brain mapping 20180110 4
We explored whether depressive symptoms measured three times during midlife were associated with structural brain alterations quantified using magnetic resonance imaging measurements of volume, cortical thickness, and intensity texture. In 192 men born in 1953 with depressive symptoms measured at age 51, 56, and 59 years, magnetic resonance imaging was performed at age 59. All data processing was performed using the Freesurfer software package except for the texture-scores that were computed usi ...[more]
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